What condition is characterized by severe exhaustion, fatigue, aches, and depression primarily affecting women in their thirties and forties?

Chronic Fatigue Syndrome (CFS) is characterized by profound fatigue that lasts for six months or longer, which is not improved by rest and may be exacerbated by physical or mental activity. Individuals with CFS often experience a combination of symptoms including severe exhaustion, fatigue, muscle or joint pain, cognitive difficulties, and sleep disturbances. It is important to note that the condition predominantly affects women in their thirties and forties, fitting the demographic described in the question.

CFS can also overlap with symptoms of other conditions, such as fibromyalgia and depressive disorders, but its distinctive characteristic is the severely debilitating fatigue that is not solely explained by other medical conditions. This highlights the complexity of the syndrome and its recognition as a unique clinical entity in health discussions, particularly regarding women's health issues in the specified age group.